Revacio it is issued in tablets on 20 mg and is applied to treatment of pulmonary arterial hypertension. Ghost effects are studied in case of application of a preparation of Revacio 20 mg at patients with the pulmonary arterial hypertension, receiving Revacio 20 mg in daily doses in the range from 20 mg to 80 mg three times per day, during the period till 12 weeks and less during 1 year. The patients receiving Sildenafil in a recommended dose of 20 mg three times per day had a low general frequency of extinction of treatment (2,9 %) and similar in comparison with the patients, applying placebos (2,9 %).
During a 16-week controlled placebo research of application of Revacio 20 to patients in daily doses from 20 mg to 80 mg in addition to introduction in case of pulmonary arterial hypertension it was comparable with treatment of patients which applied a placebo. The general frequency of extinction of treatment because of origin of ghost effects made in group Sildenafi / eprostenol 5, 2 % in comparison with 10,7 % in group of a placebo / eprostenolunwanted responses, which arose (bigger value, equal 10 %) in case of application of a preparation of Revacio 20 mg in comparison with a placebo were a headache, rushes of blood, a dyspepsia, a back pain, diarrhea and extremity pain. The collateral responses which have arisen during research in = of 3 % of patients with pulmonary arterial hypertension, applying Revacio 20 mg ™, also were frequent 1 % of a difference) for Revacioin doses 20 mg, 40 mg or 80 mg three times per day, given in the table.
Owing to Revacio 20 mg application ™ tolerance to physical activities improves and average decreases pulmonary arterial pressure. Sildenafil renders vasodilating properties and as a result in causes insignificant and tranzitorny lowering of arterial pressure. Before assigning Sildenafilcitrate, the doctor shall weigh carefully, whether vasodilation action of a preparation can such unfavorably affect patients with some accompanying statuses, for example, on patients with arterial hypotension at rest or with dehydration, heavy violation of outflow of blood from the left ventricle and dysfunction of vegetative nervous system. During the period after preparation implementation in wide medical practice it was reported about serious cardiovascular complications which on time match reception Sildenafil citrate: myocardial infarction, sudden warm death, ventricular arrhythmia, hemorrhagic stroke and transitory ischemic attack.